Players have to avoid certain hurdles, such as other vehicles and Burns' nuclear transit buses.
The player receives money upon successfully dropping off each passenger, and bonuses are obtained when they are transported in a short amount of time. The citizens of the city (controlled by the game player) earn money by driving around a vehicle for a given amount of time, picking up passengers and taking them to their destinations. Because of this, the citizens of Springfield must use their own cars as a means of safer public transport and earn money in an attempt to pay back Burns to get rid of the radioactive buses and return the town back to normal.
Burns has bought all transit systems in Springfield and has begun to create radioactive buses that threaten the public health. The Simpsons: Road Rage is based on the animated television series The Simpsons.